Medical Articles

Depression in Fibromyalgia Patients May Require Low-Dose Naltrexone to Respond: A Case Report

Jagoda Siembida, Brian Johnson


Our case highlights the potential importance of using LDN in fibromyalgia patients with comorbid depression. Symptoms of pain, depression, and functional impairment may be reduced or put into remission with improvement in human interactions – a marker of increased opioid tone. 

To say it another way, humans are social animals. We fall ill when not related. Depression is one disorder caused by unrelatedness. Fibromyalgia causes unrelatedness by impairing opioid tone. Without fixing the autoimmune unrelatedness with low-dose naltrexone, in some cases, it may be impossible to put depression into remission.

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