Medical Articles

Is Fibromyalgia An Endocrine/Endorphin Deficit Disorder? Is Low Dose Naltrexone a New Treatment Option?

Seethalakshmi Ramanathan M.D, Jaak Panksepp Ph.D., BrianJohnsonM.D


The most common medications given for newly diagnosed individuals with fibromyalgia are opioids – 56%, antiepileptics – 29%, and tricyclic antidepressants – 21%.20 If the presented hypothesis that fibromyalgia is an endocrine disorder holds true, using opioids for pain control would be the exact opposite of effective treatment, as exogenous opioids would suppress the endorphin system, eventually worsening symptoms. This case clearly identifies definitive response of symptoms of fibromyalgia to LDN in one individual. LDN may be a useful, cheap, and relatively safe medication for the management of fibromyalgia.

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