Fibromyalgia is a chronic musculoskeletal pain condition, causing brain fog, fatigue and sleeping issues.
Studies done at Stanford University found that pain and fatigue caused by fibromyalgia can be effectively treated with 4.5mg of naltrexone daily.
The mechanism of action appears to be through the reduction of cytokine inflammation in the brain which sensitizes pain-causing tissues.
Naltrexone dosing for fibromyalgia is commonly split up to 3 times per day for those with more fatigue.
- Is Fibromyalgia An Endocrine/Endorphin Deficit Disorder? Is Low Dose Naltrexone a New Treatment Option? – Seethalakshmi Ramanathan M.D, Jaak Panksepp Ph.D., Brian Johnson M.D
- Low Dose Naltrexone in the Treatment of Fibromyalgia – Samy Metyas, Christina L. Chen, Karen Yeter, John Solyman, Daniel G. Arkfeld
- Low-dose naltrexone for the treatment of fibromyalgia: findings of a small, randomized, double-blind, placebo-controlled, counterbalanced, crossover trial assessing daily pain levels – Jarred Younger, Noorulain Noor, Rebecca McCue, Sean Mackey
- Fibromyalgia Symptoms Are Reduced by Low-Dose Naltrexone: A Pilot Study – Jarred Younger, PhD, Sean Mackey, MD, PhD
- Depression in Fibromyalgia Patients May Require Low-Dose Naltrexone to Respond: A Case Report – Jagoda Siembida, Brian Johnson