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Low-dose naltrexone plays antineoplastic role in cervical cancer progression through suppressing PI3K/AKT/mTOR pathway

Ning Liua, Limei Yana, Fengping Shan, Xiaonai Wang, Na Qu, Mike K Handley, Mingxing Ma

The incidence of cervical cancer is increasing annually worldwide. Low-dose naltrexone (LDN) has been reported to delay tumor progression, but the mechanism remains unclear. Here, we found that low-dose naltrexone could upregulate the expression of OGFr. Additionally, LDN could suppress the abilities of colony formation, migration and invasion in cervical cancer cells. LDN could also inhibit cervical cancer progression in mice model. Moreover, LDN indirectly reduced the expressions of PI3K, pAKT and mTOR in vitro and in vivo. Therefore, LDN may be considered a potential treatment option for cervical cancer.

205 replies on “Low-dose naltrexone plays antineoplastic role in cervical cancer progression through suppressing PI3K/AKT/mTOR pathway”

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Thanks for your article on the travel industry. We would also like contribute that if you are one senior considering traveling, it can be absolutely crucial to buy traveling insurance for senior citizens. When traveling, golden-agers are at biggest risk of having a medical emergency. Obtaining the right insurance coverage package in your age group can safeguard your health and provide peace of mind.

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Thanks for another wonderful article. Where else may just anybody get that kind of info in such an ideal way of writing? I’ve a presentation subsequent week, and I’m on the look for such info.

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