Ning Liua, Limei Yana, Fengping Shan, Xiaonai Wang, Na Qu, Mike K Handley, Mingxing Ma
The incidence of cervical cancer is increasing annually worldwide. Low-dose naltrexone (LDN) has been reported to delay tumor progression, but the mechanism remains unclear. Here, we found that low-dose naltrexone could upregulate the expression of OGFr. Additionally, LDN could suppress the abilities of colony formation, migration and invasion in cervical cancer cells. LDN could also inhibit cervical cancer progression in mice model. Moreover, LDN indirectly reduced the expressions of PI3K, pAKT and mTOR in vitro and in vivo. Therefore, LDN may be considered a potential treatment option for cervical cancer.
2,622 replies on “Low-dose naltrexone plays antineoplastic role in cervical cancer progression through suppressing PI3K/AKT/mTOR pathway”
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An insurance policy will set out in detail which perils are covered by the
coverage and which are not.
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Furthermore, i believe that mesothelioma cancer is a rare form of melanoma that is often found in those previously subjected to asbestos. Cancerous cells form from the mesothelium, which is a protective lining which covers a lot of the body’s body organs. These cells ordinarily form within the lining of your lungs, tummy, or the sac that really encircles the heart. Thanks for giving your ideas.
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An insurance premium paid at present offers
coverage for losses that might come up many years in the
future.
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