Wai M. Liu Katherine A. Scott Jayne L. Dennis Elwira Kaminska Alan J. Levett Angus G. Dalgleish
In conclusion, these data highlight the existence of a fundamental difference in the mechanism by which naltrexone elicits an effect. By using gene expression analysis, we showed there was a difference in the gene-fingerprint of the drug when used at two different concentration ranges. Specifically, LDN resulted in explicit changes to genes involved in cell cycle control, which were absent when doses were much higher. Further experimentation that was steered by the gene data revealed the efficacy of LDN to be enhanced by adaptations to treatment schedules. These improvements were linked to our attempts to negate a cell cycle and/or cell death blockade caused by the presence of the drug. Additionally, by utilising the priming effect of LDN, the cytotoxic effect of common chemotherapy drugs could be increased through the sequential administration of the drugs. Overall, these studies provide further evidence to support to role of LDN as an anticancer agent.
927 replies on “Naltrexone at low doses upregulates a unique gene expression not seen with normal doses: Implications for its use in cancer therapy”
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I additionally believe that mesothelioma is a scarce form of many forms of cancer that is often found in people previously subjected to asbestos. Cancerous tissues form inside the mesothelium, which is a protecting lining that covers almost all of the body’s organs. These cells ordinarily form while in the lining with the lungs, mid-section, or the sac which actually encircles the heart. Thanks for discussing your ideas.
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It is indeed my belief that mesothelioma will be the most dangerous cancer. It has unusual traits. The more I actually look at it the greater I am convinced it does not react like a real solid human cancer. If mesothelioma is actually a rogue viral infection, hence there is the chance of developing a vaccine and offering vaccination for asbestos exposed people who are vulnerable to high risk involving developing long term asbestos related malignancies. Thanks for discussing your ideas for this important ailment.
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