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Use of low-dose naltrexone in the management of chronic pain conditions: A systematic review

Elizabeth Hatfield DDS, Kristine Phillips DDS, Sahar Swidan PharmD, LawrenceAshmanDDS

https://doi.org/10.1016/j.adaj.2020.08.019

Conclusions and Practical Implications

Low-dose naltrexone provides an alternative in medical management of chronic pain disorders as a novel anti-inflammatory and immunomodulator. It can offer additional management options, as orofacial pain conditions share characteristics with other chronic pain disorders. Owing to the size and heterogeneity of the studies, more large-scale studies are needed, along with additional studies assessing orofacial pain response to low-dose naltrexone.

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